GBA1
MOLECULAR TARGETglucosylceramidase beta 1
GBA1 (glucosylceramidase beta 1) is targeted by 18 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting GBA1
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | tamoxifen | 5.88 | 358 |
| 2 | duvoglustat | 4.34 | 76 |
| 3 | mexiletine | 3.99 | 53 |
| 4 | miglitol | 3.61 | 36 |
| 5 | afegostat | 3.04 | 20 |
| 6 | ambroxol | 2.48 | 11 |
| 7 | dideoxyiminoxylitol | 1.95 | 6 |
| 8 | Chlorhexidine | 1.10 | 2 |
| 9 | Genistein | 0.69 | 1 |
| 10 | 1-Deoxynojirimycin | 0.69 | 1 |
| 11 | trichostatic acid [Supplementary Concept] related to trichostatin | 0.69 | 1 |
| 12 | bdb chembl2170199 | 0.69 | 1 |
| 13 | bdb chembl3354016 | 0.69 | 1 |
| 14 | bdb chembl3354019 | 0.69 | 1 |
| 15 | bdb chembl3354029 | 0.69 | 1 |
| 16 | bdb chembl3354032 | 0.69 | 1 |
| 17 | bdb chembl3354015 | 0.69 | 1 |
| 18 | bdb chembl3354017 | 0.69 | 1 |
About GBA1 as a Drug Target
GBA1 (glucosylceramidase beta 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 18 compounds with documented GBA1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
GBA1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.