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Genistein

An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.

300+ PubMed studies analyzed · 3 RCTs · Evidence Score: 40.3

Research Domains

Genistein has been studied across 23 research domains including 🔬 Oncology, 🧬 Hormones, 🔬 Inflammation, 🫁 Liver & Detox, 🦴 Bone & Joint. The primary research focus is 🔬 Oncology with 29% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Genistein, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

Pueraria
28 shared targets
Apigenin
41 shared targets
chrysin
31 shared targets
Kaempferols
28 shared targets
Emodin
27 shared targets
Daunorubicin
28 shared targets
Leflunomide
20 shared targets
Azacitidine
19 shared targets
Azacitidine
19 shared targets
Riluzole
19 shared targets
Loading evidence profile...

This evidence profile for Genistein is generated deterministically from 300 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.