HMGB1
MOLECULAR TARGEThigh mobility group box 1
HMGB1 (high mobility group box 1) is targeted by 4 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting HMGB1
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | methotrexate | 6.00 | 404 |
| 2 | glycyrrhizin | 3.95 | 51 |
| 3 | Methotrexate | 1.10 | 2 |
| 4 | Salicylic Acid | 1.10 | 2 |
About HMGB1 as a Drug Target
HMGB1 (high mobility group box 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 4 compounds with documented HMGB1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
HMGB1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.