What compounds target IDO1?

BiohacksAI has identified 28 compounds that interact with IDO1 (indoleamine 2,3-dioxygenase 1). Top compounds include: ebselen, lapachone, epacadostat, norharmane, bifonazole. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is IDO1 (indoleamine 2,3-dioxygenase 1)?

IDO1 is indoleamine 2,3-dioxygenase 1. It is a molecular target for 28 compounds documented in PubMed bioassay data. UniProt ID: P14902. NCBI Gene ID: 3620.

IDO1

MOLECULAR TARGET

indoleamine 2,3-dioxygenase 1

UniProt: P14902 NCBI Gene: 362028 compounds

IDO1 (indoleamine 2,3-dioxygenase 1) is targeted by 28 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting IDO1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	ebselen	4.74	113
2	lapachone	4.34	76
3	epacadostat	4.01	54
4	norharmane	3.76	42
5	bifonazole	3.71	40
6	naphthoquinone	3.58	35
7	tryptanthrin	3.47	31
8	l 1 methyltryptophan	3.40	29
9	necrostatin	3.30	26
10	benzohydroxamate	3.26	25
11	2 methoxy 14 naphthoquinone	2.77	15
12	dichlon	2.77	15
13	purpurogallin	2.71	14
14	dichlorophen	2.64	13
15	pf 06840003	2.64	13
16	indazole	2.56	12
17	sulconazole	2.48	11
18	oxiconazole	2.48	11
19	navoximod	2.48	11
20	acetylserotonin	2.48	11
21	12 naphthoquinone	2.30	9
22	caulerpin	2.08	7
23	sertaconazole	2.08	7
24	Vitamin K 3	1.95	6
25	Miconazole	1.61	4
26	Econazole	1.10	2
27	juglone hydroxylase [Supplementary Concept] catalyzes	1.10	2
28	celastrol	0.69	1

About IDO1 as a Drug Target

IDO1 (indoleamine 2,3-dioxygenase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 28 compounds with documented IDO1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

IDO1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.