What compounds target KDM1A?

BiohacksAI has identified 29 compounds that interact with KDM1A (lysine demethylase 1A). Top compounds include: erlotinib, osimertinib, amsacrine, raloxifene, isoquercetin. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is KDM1A (lysine demethylase 1A)?

KDM1A is lysine demethylase 1A. It is a molecular target for 29 compounds documented in PubMed bioassay data. UniProt ID: O60341. NCBI Gene ID: 23028.

KDM1A

MOLECULAR TARGET

lysine demethylase 1A

UniProt: O60341 NCBI Gene: 2302829 compounds

KDM1A (lysine demethylase 1A) is targeted by 29 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting KDM1A

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	erlotinib	5.55	256
2	osimertinib	5.03	152
3	amsacrine	4.82	123
4	raloxifene	4.77	117
5	isoquercetin	4.50	89
6	tranylcypromine	4.48	87
7	promazine	4.19	65
8	mangostin	4.14	62
9	biochanin	4.14	62
10	baicalin	3.91	49
11	wogonin	3.61	36
12	diosmetin	3.58	35
13	gsk2879552	3.14	22
14	diosmin	3.09	21
15	dihydrotanshinone i	2.89	17
16	tanshinone i	2.89	17
17	domatinostat	2.77	15
18	fenoldopam	2.71	14
19	tranylcypromine hydrochloride	2.56	12
20	tranylcypromine	2.40	10
21	iadademstat	2.40	10
22	palmitine	2.40	10
23	icaritin	2.40	10
24	jatrorrhizine	2.20	8
25	Phenelzine	1.79	5
26	vafidemstat	1.79	5
27	Berberine	0.69	1
28	Quercetin	0.69	1
29	Rutin	0.69	1

About KDM1A as a Drug Target

KDM1A (lysine demethylase 1A) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 29 compounds with documented KDM1A interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

KDM1A inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.