LRRK2
MOLECULAR TARGETleucine rich repeat kinase 2
LRRK2 (leucine rich repeat kinase 2) is targeted by 28 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting LRRK2
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | erlotinib | 5.55 | 256 |
| 2 | tofacitinib | 4.65 | 104 |
| 3 | alvocidib | 4.52 | 91 |
| 4 | ponatinib | 4.26 | 70 |
| 5 | ruxolitinib | 4.23 | 68 |
| 6 | bosutinib | 4.08 | 58 |
| 7 | midostaurin | 3.85 | 46 |
| 8 | brigatinib | 3.81 | 44 |
| 9 | nintedanib | 3.61 | 36 |
| 10 | canertinib | 3.53 | 33 |
| 11 | y 27632 | 3.47 | 31 |
| 12 | tae 684 | 3.43 | 30 |
| 13 | fedratinib | 3.40 | 29 |
| 14 | adenine | 3.22 | 24 |
| 15 | dovitinib | 3.09 | 21 |
| 16 | lestaurtinib | 3.04 | 20 |
| 17 | ruboxistaurin | 2.94 | 18 |
| 18 | r 406 | 2.83 | 16 |
| 19 | kw 2449 | 2.64 | 13 |
| 20 | mli 2 | 2.64 | 13 |
| 21 | ast 487 | 2.56 | 12 |
| 22 | su 014813 | 2.20 | 8 |
| 23 | rebastinib | 2.20 | 8 |
| 24 | gsk 269962a | 2.08 | 7 |
| 25 | dnl 201 | 1.79 | 5 |
| 26 | Axitinib | 1.10 | 2 |
| 27 | hydroxyfasudil [Supplementary Concept] | 1.10 | 2 |
| 28 | pictilisib | 0.69 | 1 |
About LRRK2 as a Drug Target
LRRK2 (leucine rich repeat kinase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 28 compounds with documented LRRK2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
LRRK2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.