MAPKAPK2
MOLECULAR TARGETMAPK activated protein kinase 2
MAPKAPK2 (MAPK activated protein kinase 2) is targeted by 21 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting MAPKAPK2
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | tozasertib | 4.33 | 75 |
| 2 | ponatinib | 4.26 | 70 |
| 3 | silmitasertib | 3.78 | 43 |
| 4 | regorafenib | 3.56 | 34 |
| 5 | rottlerin | 3.26 | 25 |
| 6 | lestaurtinib | 3.04 | 20 |
| 7 | lenvatinib | 3.04 | 20 |
| 8 | bms 754807 | 2.30 | 9 |
| 9 | rebastinib | 2.20 | 8 |
| 10 | gsk 1070916 | 2.20 | 8 |
| 11 | encorafenib | 2.20 | 8 |
| 12 | amg 900 | 2.08 | 7 |
| 13 | cep 32496 | 1.95 | 6 |
| 14 | bafetinib | 1.95 | 6 |
| 15 | tanzisertib | 1.95 | 6 |
| 16 | talmapimod | 1.95 | 6 |
| 17 | osi 632 | 1.79 | 5 |
| 18 | fgfr inhibitor debio 1347 | 1.79 | 5 |
| 19 | losmapimod | 1.79 | 5 |
| 20 | Adenosine Triphosphate | 1.10 | 2 |
| 21 | Afatinib | 0.69 | 1 |
About MAPKAPK2 as a Drug Target
MAPKAPK2 (MAPK activated protein kinase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 21 compounds with documented MAPKAPK2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
MAPKAPK2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.