What compounds target OPRM1?

BiohacksAI has identified 47 compounds that interact with OPRM1 (opioid receptor mu 1). Top compounds include: Morphine, Naloxone, Fentanyl, Nalbuphine, Butorphanol. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is OPRM1 (opioid receptor mu)?

OPRM1 is opioid receptor mu 1. It is a molecular target for 47 compounds documented in PubMed bioassay data. UniProt ID: P35372. NCBI Gene ID: 4988.

OPRM1

MOLECULAR TARGET

opioid receptor mu 1

UniProt: P35372 NCBI Gene: 498847 compounds

OPRM1 (opioid receptor mu 1) is targeted by 47 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting OPRM1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Morphine	5.18	176
2	Naloxone	4.44	84
3	Fentanyl	3.61	36
4	Nalbuphine	3.14	22
5	Butorphanol	2.77	15
6	Oxycodone	2.71	14
7	Levorphanol	2.64	13
8	Nalorphine	2.56	12
9	Pentazocine	2.48	11
10	Diprenorphine	2.20	8
11	Sufentanil	2.20	8
12	Levallorphan	2.08	7
13	Meperidine	2.08	7
14	Codeine	1.95	6
15	Etorphine	1.95	6
16	cbd	1.61	4
17	cannabidiol	1.61	4
18	Dihydromorphine	1.61	4
19	Meptazinol	1.61	4
20	Alfentanil	1.39	3
21	Hydromorphone	1.39	3
22	Tramadol	1.10	2
23	Cyclazocine	1.10	2
24	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	1.10	2
25	hydrocodone	1.10	2
26	Ibogaine	1.10	2
27	Thebaine	1.10	2
28	Apigenin 5,7,4'-trihydroxy-flavone,	0.69	1
29	Kaempferols	0.69	1
30	alpha-Endorphin	0.69	1
31	alsterpaullone	0.69	1
32	beta-Endorphin	0.69	1
33	Buprenorphine	0.69	1
34	Celecoxib	0.69	1
35	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	0.69	1
36	Digoxin	0.69	1
37	Dihydroergotamine	0.69	1
38	Diphenoxylate	0.69	1
39	Flunarizine Flunarizine is	0.69	1
40	Fluspirilene	0.69	1
41	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	0.69	1
42	Ondansetron	0.69	1
43	Phenazocine	0.69	1
44	Ritodrine	0.69	1
45	Somatostatin	0.69	1
46	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	0.69	1
47	alphitonin [Supplementary Concept] from	0.69	1

About OPRM1 as a Drug Target

OPRM1 (opioid receptor mu 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 47 compounds with documented OPRM1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

OPRM1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.