BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
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Diphenoxylate

A MEPERIDINE congener used as an antidiarrheal, usually in combination with ATROPINE. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity.

294+ PubMed studies analyzed · 22 RCTs · Evidence Score: 45.3

Research Domains

Diphenoxylate has been studied across 15 research domains including 🦠 Gut & Microbiome, 💊 Pain, 🔬 Oncology, 🦴 Bone & Joint, 😴 Sleep. The primary research focus is 🦠 Gut & Microbiome with 37% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Diphenoxylate, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

dendrobium
2 shared targets
lithospermum
2 shared targets
alisma
2 shared targets
allium
2 shared targets
cnidium
2 shared targets
hirudo
2 shared targets
scolopendra
2 shared targets
belamcanda
2 shared targets
Foeniculum
2 shared targets
prunus
2 shared targets
Loading evidence profile...

This evidence profile for Diphenoxylate is generated deterministically from 294 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.