What compounds target PKN1?

BiohacksAI has identified 44 compounds that interact with PKN1 (protein kinase N1). Top compounds include: tofacitinib, alvocidib, tozasertib, ruxolitinib, bosutinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is PKN1 (protein kinase N1)?

PKN1 is protein kinase N1. It is a molecular target for 44 compounds documented in PubMed bioassay data. UniProt ID: Q16512. NCBI Gene ID: 5585.

PKN1

MOLECULAR TARGET

protein kinase N1

UniProt: Q16512 NCBI Gene: 558544 compounds

PKN1 (protein kinase N1) is targeted by 44 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting PKN1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	tofacitinib	4.65	104
2	alvocidib	4.52	91
3	tozasertib	4.33	75
4	ruxolitinib	4.23	68
5	bosutinib	4.08	58
6	midostaurin	3.85	46
7	silmitasertib	3.78	43
8	fasudil	3.66	38
9	nintedanib	3.61	36
10	baricitinib	3.56	34
11	tae 684	3.43	30
12	fedratinib	3.40	29
13	sgi 1776	3.26	25
14	dovitinib	3.09	21
15	at 9283	3.09	21
16	lestaurtinib	3.04	20
17	pf 03758309	3.00	19
18	ruboxistaurin	2.94	18
19	r 406	2.83	16
20	k 252a	2.83	16
21	pf 00562271	2.77	15
22	sotrastaurin	2.77	15
23	capivasertib	2.77	15
24	crenolanib	2.71	14
25	kw 2449	2.64	13
26	gsk 690693	2.64	13
27	zotiraciclib	2.56	12
28	ripasudil	2.40	10
29	hydroxyfasudil	2.40	10
30	azd 7762	2.30	9
31	su 014813	2.20	8
32	decernotinib	2.20	8
33	y 39983	2.20	8
34	cyc 116	2.08	7
35	enzastaurin	2.08	7
36	uprosertib	1.95	6
37	lgh 447	1.95	6
38	pf 03814735	1.79	5
39	ucn 01	1.79	5
40	afuresertib	1.79	5
41	sar 407899 free base	1.79	5
42	norlichexanthone	1.79	5
43	hydroxyfasudil [Supplementary Concept]	1.10	2
44	Quercetin	0.69	1

About PKN1 as a Drug Target

PKN1 (protein kinase N1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 44 compounds with documented PKN1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

PKN1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.