What compounds target PKN2?

BiohacksAI has identified 33 compounds that interact with PKN2 (protein kinase N2). Top compounds include: tofacitinib, tozasertib, bosutinib, midostaurin, fasudil. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is PKN2 (protein kinase N2)?

PKN2 is protein kinase N2. It is a molecular target for 33 compounds documented in PubMed bioassay data. NCBI Gene ID: 5586.

PKN2

MOLECULAR TARGET

protein kinase N2

NCBI Gene: 558633 compounds

PKN2 (protein kinase N2) is targeted by 33 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting PKN2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	tofacitinib	4.65	104
2	tozasertib	4.33	75
3	bosutinib	4.08	58
4	midostaurin	3.85	46
5	fasudil	3.66	38
6	nintedanib	3.61	36
7	baricitinib	3.56	34
8	y 27632	3.47	31
9	tae 684	3.43	30
10	dovitinib	3.09	21
11	jnj 7706621	3.09	21
12	at 9283	3.09	21
13	lestaurtinib	3.04	20
14	ruboxistaurin	2.94	18
15	r 406	2.83	16
16	k 252a	2.83	16
17	crenolanib	2.71	14
18	kw 2449	2.64	13
19	gsk 690693	2.64	13
20	zotiraciclib	2.56	12
21	gsk 461364	2.40	10
22	ripasudil	2.40	10
23	hydroxyfasudil	2.40	10
24	azd 7762	2.30	9
25	su 014813	2.20	8
26	y 39983	2.20	8
27	rg 547	2.08	7
28	hydroxyfasudil [Supplementary Concept]	1.79	5
29	ucn 01	1.79	5
30	sar 407899 free base	1.79	5
31	alsterpaullone	0.69	1
32	Axitinib	0.69	1
33	Dasatinib	0.69	1

About PKN2 as a Drug Target

PKN2 (protein kinase N2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 33 compounds with documented PKN2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

PKN2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.