PRKACA
MOLECULAR TARGETprotein kinase cAMP-activated catalytic subunit alpha
PRKACA (protein kinase cAMP-activated catalytic subunit alpha) is targeted by 24 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting PRKACA
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | ponatinib | 4.26 | 70 |
| 2 | midostaurin | 3.85 | 46 |
| 3 | sb 202190 | 3.64 | 37 |
| 4 | baricitinib | 3.56 | 34 |
| 5 | tae 684 | 3.43 | 30 |
| 6 | gf 109203 | 3.40 | 29 |
| 7 | bms 777607 | 3.37 | 28 |
| 8 | linifanib | 3.33 | 27 |
| 9 | at 9283 | 3.09 | 21 |
| 10 | lestaurtinib | 3.04 | 20 |
| 11 | pf 03758309 | 3.00 | 19 |
| 12 | ruboxistaurin | 2.94 | 18 |
| 13 | r 406 | 2.83 | 16 |
| 14 | capivasertib | 2.77 | 15 |
| 15 | gsk 690693 | 2.64 | 13 |
| 16 | ast 487 | 2.56 | 12 |
| 17 | balanol | 2.30 | 9 |
| 18 | hydroxyfasudil [Supplementary Concept] | 2.20 | 8 |
| 19 | y 39983 | 2.20 | 8 |
| 20 | enzastaurin | 2.08 | 7 |
| 21 | uprosertib | 1.95 | 6 |
| 22 | afuresertib | 1.79 | 5 |
| 23 | sar 407899 free base | 1.79 | 5 |
| 24 | Sphingosine | 0.69 | 1 |
About PRKACA as a Drug Target
PRKACA (protein kinase cAMP-activated catalytic subunit alpha) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 24 compounds with documented PRKACA interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
PRKACA inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.