PRKDC
MOLECULAR TARGETprotein kinase, DNA-activated, catalytic subunit
PRKDC (protein kinase, DNA-activated, catalytic subunit) is targeted by 25 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting PRKDC
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | ly 294002 | 4.84 | 126 |
| 2 | alpha naphthoflavone | 4.67 | 106 |
| 3 | dactolisib | 4.25 | 69 |
| 4 | trifluoperazine | 4.25 | 69 |
| 5 | pi 103 | 4.17 | 64 |
| 6 | idelalisib | 4.13 | 61 |
| 7 | cgs 15943 | 3.47 | 31 |
| 8 | buparlisib | 3.40 | 29 |
| 9 | omipalisib | 3.14 | 22 |
| 10 | ku 55933 | 2.94 | 18 |
| 11 | fimepinostat | 2.89 | 17 |
| 12 | apitolisib | 2.71 | 14 |
| 13 | isogranulatimide | 2.56 | 12 |
| 14 | torin1 | 2.40 | 10 |
| 15 | cb 5083 | 2.40 | 10 |
| 16 | berzosertib | 2.30 | 9 |
| 17 | azd 6482 | 2.30 | 9 |
| 18 | bimiralisib | 2.30 | 9 |
| 19 | azd 7648 | 2.30 | 9 |
| 20 | osi 027 | 2.08 | 7 |
| 21 | elimusertib | 2.08 | 7 |
| 22 | ceralasertib | 2.08 | 7 |
| 23 | pilaralisib | 1.95 | 6 |
| 24 | eganelisib | 1.79 | 5 |
| 25 | Wortmannin | 0.69 | 1 |
About PRKDC as a Drug Target
PRKDC (protein kinase, DNA-activated, catalytic subunit) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 25 compounds with documented PRKDC interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
PRKDC inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.