What compounds target ROCK2?

BiohacksAI has identified 48 compounds that interact with ROCK2 (Rho associated coiled-coil containing protein kinase 2). Top compounds include: tofacitinib, alvocidib, foretinib, vandetanib, ruxolitinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ROCK2 (Rho associated coiled-coil)?

ROCK2 is Rho associated coiled-coil containing protein kinase 2. It is a molecular target for 48 compounds documented in PubMed bioassay data. UniProt ID: O75116. NCBI Gene ID: 9475.

ROCK2

MOLECULAR TARGET

Rho associated coiled-coil containing protein kinase 2

UniProt: O75116 NCBI Gene: 947548 compounds

ROCK2 (Rho associated coiled-coil containing protein kinase 2) is targeted by 48 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ROCK2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	tofacitinib	4.65	104
2	alvocidib	4.52	91
3	foretinib	4.34	76
4	vandetanib	4.30	73
5	ruxolitinib	4.23	68
6	ceritinib	4.19	65
7	bosutinib	4.08	58
8	midostaurin	3.85	46
9	fasudil	3.66	38
10	baricitinib	3.56	34
11	y 27632	3.47	31
12	tae 684	3.43	30
13	fedratinib	3.40	29
14	linifanib	3.33	27
15	hydroxyfasudil [Supplementary Concept]	3.30	26
16	dovitinib	3.09	21
17	upadacitinib	3.09	21
18	lestaurtinib	3.04	20
19	momelotinib	2.89	17
20	r 406	2.83	16
21	capivasertib	2.77	15
22	pha 665752	2.71	14
23	kw 2449	2.64	13
24	gsk 690693	2.64	13
25	ast 487	2.56	12
26	zotiraciclib	2.56	12
27	ripasudil	2.40	10
28	hydroxyfasudil	2.40	10
29	belumosudil	2.30	9
30	su 014813	2.20	8
31	gsk 1070916	2.20	8
32	decernotinib	2.20	8
33	y 39983	2.20	8
34	cyc 116	2.08	7
35	rg 547	2.08	7
36	gsk 269962a	2.08	7
37	uprosertib	1.95	6
38	lx 7101	1.95	6
39	netarsudil	1.95	6
40	ucn 01	1.79	5
41	afuresertib	1.79	5
42	sar 407899 free base	1.79	5
43	kenpaullone	1.10	2
44	Kinetin	0.69	1
45	alsterpaullone	0.69	1
46	Crizotinib	0.69	1
47	Edaravone	0.69	1
48	sp600125	0.69	1

About ROCK2 as a Drug Target

ROCK2 (Rho associated coiled-coil containing protein kinase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 48 compounds with documented ROCK2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ROCK2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.