What compounds target SLC22A8?

BiohacksAI has identified 26 compounds that interact with SLC22A8 (solute carrier family 22 member 8). Top compounds include: Probenecid, Dicloxacillin, Oxacillin, Penicillin G, cefadroxil. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is SLC22A8 (solute carrier family)?

SLC22A8 is solute carrier family 22 member 8. It is a molecular target for 26 compounds documented in PubMed bioassay data. UniProt ID: Q8TCC7. NCBI Gene ID: 9376.

SLC22A8

MOLECULAR TARGET

solute carrier family 22 member 8

UniProt: Q8TCC7 NCBI Gene: 937626 compounds

SLC22A8 (solute carrier family 22 member 8) is targeted by 26 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting SLC22A8

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Probenecid	2.40	10
2	Dicloxacillin	1.39	3
3	Oxacillin	1.39	3
4	Penicillin G	1.39	3
5	cefadroxil	1.10	2
6	Thioctic Acid	0.69	1
7	Carnitine	0.69	1
8	Ampicillin Semi-synthetic derivative of penicillin that functions as	0.69	1
9	Azlocillin	0.69	1
10	cefaclor	0.69	1
11	Cefamandole Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as	0.69	1
12	Cefazolin	0.69	1
13	Cefoperazone Semisynthetic broad-spectrum cephalosporin with	0.69	1
14	cefotaxime	0.69	1
15	Cefoxitin	0.69	1
16	Ceftriaxone	0.69	1
17	Cephaloridine	0.69	1
18	Cloxacillin	0.69	1
19	Dinoprost	0.69	1
20	Dinoprostone	0.69	1
21	Indomethacin	0.69	1
22	Methicillin	0.69	1
23	Nafcillin	0.69	1
24	Penicillin V	0.69	1
25	piperacillin	0.69	1
26	Tazobactam	0.69	1

About SLC22A8 as a Drug Target

SLC22A8 (solute carrier family 22 member 8) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 26 compounds with documented SLC22A8 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

SLC22A8 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.