arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) vs deguelin
Mechanistic comparison of arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from and deguelin [Supplementary Concept] based on molecular target overlap from BindingDB and ChEMBL binding affinity data.
6
Shared Targets
33%
Jaccard Similarity
27%
IDF-Weighted Similarity
Jaccard measures raw target overlap. IDF-weighted downweights promiscuous hub targets (e.g. CYP enzymes) that bind many compounds non-specifically.
Evidence Comparison
Target Overlap
arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) and deguelin share 6 molecular targets based on binding affinity data from BindingDB (Kd/IC50 ≤ 10 µM) and ChEMBL. A Jaccard index of 0.333 means 33% of the combined target set is bound by both compounds. The IDF-weighted score of 0.270 accounts for non-specific binding to metabolic enzymes.
Note: High target overlap does not imply identical mechanism or therapeutic equivalence. Binding affinity, tissue distribution, bioavailability, and downstream signaling differ significantly between compounds even when they bind the same protein.
Frequently Asked Questions
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