Question 1

What compounds affect the Resolution of AP sites via the single-nucleotide replacement pathway pathway?

Accepted Answer

30 compounds in the BiohacksAI corpus have documented interactions with genes in the Resolution of AP sites via the single-nucleotide replacement pathway pathway (Reactome ID: R-HSA-110381). These compounds target 2 genes within this pathway.

Question 2

What genes are in the Resolution of AP sites via the single-nucleotide replacement pathway pathway?

Accepted Answer

The Resolution of AP sites via the single-nucleotide replacement pathway pathway involves 2 genes. Key genes include: APEX1, POLB.

#	Compound	Targets Hit	Studies
1	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
2	Aurintricarboxylic Acid	—	184
3	Oleanolic Acid	—	300
4	stigmasterol	—	300
5	4-Hydroxybenzoate-3-Monooxygenase	—	300
6	Ursolic Acid	—	300
7	Methyldopa	—	297
8	DEAD-box RNA Helicases	—	169
9	Thioctic Acid	—	298
10	egcg	—	300
11	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
12	Methylene Blue	—	200
13	Quercetin	—	300
14	Rosmarinic Acid	—	300
15	Rutin	—	300
16	Methotrexate	—	289
17	calycosin	—	300
18	Demeclocycline	—	5
19	Dequalinium	—	46
20	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
21	Hexachlorophene	—	300
22	Idarubicin	—	299
23	Oxytetracycline	—	300
24	piceatannol	—	300
25	Nitroprusside	—	299
26	sp600125	—	117
27	Stavudine	—	298
28	streptonigrin	—	299
29	alphitonin [Supplementary Concept] from	—	300
30	Thioctic Acid	—	300

BiohacksAI

Resolution of AP sites via the single-nucleotide replacement pathway

Genes in this Pathway

Compounds Affecting Resolution of AP sites via the single-nucleotide replacement pathway

About the Resolution of AP sites via the single-nucleotide replacement pathway Pathway