BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
REACTOME PATHWAYThe BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members pathway (Reactome ID: R-HSA-111453) involves 4 genes and is affected by 15 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | paxilline | — | 42 |
| 2 | Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). | — | 300 |
| 3 | Anthralin | — | 299 |
| 4 | Aurintricarboxylic Acid | — | 184 |
| 5 | Domperidone | — | 299 |
| 6 | Metergoline | — | 144 |
| 7 | Masoprocol | — | 300 |
| 8 | Oxytetracycline | — | 300 |
| 9 | Tetracycline | — | 300 |
| 10 | vinblastine sulfate | — | 81 |
| 11 | Niclosamide | — | 299 |
| 12 | Fingolimod Hydrochloride | — | 56 |
| 13 | Celecoxib | — | 295 |
| 14 | egcg | — | 300 |
| 15 | Anisomycin | — | 247 |
About the BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Pathway
The BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members pathway is catalogued in Reactome (ID: R-HSA-111453) and involves 4 genes. In the BiohacksAI corpus, 15 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BAD, BCL2L1, BCL2L11, STAT3.