What compounds target STAT3?

BiohacksAI has identified 135 compounds that interact with STAT3 (signal transducer and activator of transcription 3). Top compounds include: nitazoxanide, baricitinib, piplartine, bardoxolone methyl, napabucasin. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is STAT3 (signal transducer and)?

STAT3 is signal transducer and activator of transcription 3. It is a molecular target for 135 compounds documented in PubMed bioassay data. UniProt ID: P40763. NCBI Gene ID: 6774.

STAT3

MOLECULAR TARGET

signal transducer and activator of transcription 3

UniProt: P40763 NCBI Gene: 6774135 compounds

STAT3 (signal transducer and activator of transcription 3) is targeted by 135 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting STAT3

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	nitazoxanide	3.97	52
2	baricitinib	3.56	34
3	piplartine	3.53	33
4	bardoxolone methyl	3.47	31
5	napabucasin	3.43	30
6	lestaurtinib	3.04	20
7	momelotinib	2.89	17
8	curcumin pyrazole	2.77	15
9	Niclosamide	2.56	12
10	deucravacitinib	2.48	11
11	azd 1480	2.30	9
12	levomenol	2.20	8
13	delgocitinib	1.95	6
14	Fingolimod Hydrochloride	1.10	2
15	agastache rugosa	1.00	1
16	Garlic	1.00	1
17	allium tuberosum	1.00	1
18	aloe vera	1.00	1
19	anemarrhena asphodeloides	1.00	1
20	apis mellifera	1.00	1
21	arctium lappa	1.00	1
22	artemisia annua	1.00	1
23	artemisia argyi	1.00	1
24	aster tataricus	1.00	1
25	atractylodes macrocephala	1.00	1
26	bupleurum chinense	1.00	1
27	carthamus tinctorius	1.00	1
28	Centella	1.00	1
29	chaenomeles speciosa	1.00	1
30	citrus reticulata	1.00	1
31	crataegus pinnatifida	1.00	1
32	Curcuma	1.00	1
33	cuscuta chinensis	1.00	1
34	cynomorium songaricum	1.00	1
35	dimocarpus longan	1.00	1
36	ephedra sinica	1.00	1
37	eucommia ulmoides	1.00	1
38	Foeniculum	1.00	1
39	forsythia suspensa	1.00	1
40	fritillaria cirrhosa	1.00	1
41	Ginkgo biloba	1.00	1
42	glycine max	1.00	1
43	glycyrrhiza uralensis	1.00	1
44	ligusticum chuanxiong	1.00	1
45	lilium lancifolium	1.00	1
46	litchi chinensis	1.00	1
47	lobelia chinensis	1.00	1
48	lonicera japonica	1.00	1
49	morus alba	1.00	1
50	Nelumbo	1.00	1

Showing top 50 of 135 compounds. Use the BiohacksAI search to explore all STAT3 modulators.

About STAT3 as a Drug Target

STAT3 (signal transducer and activator of transcription 3) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 135 compounds with documented STAT3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

STAT3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.