STAT3
MOLECULAR TARGETsignal transducer and activator of transcription 3
STAT3 (signal transducer and activator of transcription 3) is targeted by 15 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting STAT3
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | nitazoxanide | 3.97 | 52 |
| 2 | baricitinib | 3.56 | 34 |
| 3 | piplartine | 3.53 | 33 |
| 4 | bardoxolone methyl | 3.47 | 31 |
| 5 | napabucasin | 3.43 | 30 |
| 6 | lestaurtinib | 3.04 | 20 |
| 7 | momelotinib | 2.89 | 17 |
| 8 | curcumin pyrazole | 2.77 | 15 |
| 9 | Niclosamide | 2.56 | 12 |
| 10 | deucravacitinib | 2.48 | 11 |
| 11 | azd 1480 | 2.30 | 9 |
| 12 | levomenol | 2.20 | 8 |
| 13 | delgocitinib | 1.95 | 6 |
| 14 | Fingolimod Hydrochloride | 1.10 | 2 |
| 15 | Celecoxib | 0.69 | 1 |
About STAT3 as a Drug Target
STAT3 (signal transducer and activator of transcription 3) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 15 compounds with documented STAT3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
STAT3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.