Presynaptic depolarization and calcium channel opening
REACTOME PATHWAYThe Presynaptic depolarization and calcium channel opening pathway (Reactome ID: R-HSA-112308) involves 3 genes and is affected by 12 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Presynaptic depolarization and calcium channel opening
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Flunarizine Flunarizine is | — | 299 |
| 2 | Pregabalin | — | 996 |
| 3 | omega-Conotoxin GVIA | — | 300 |
| 4 | DEAD-box RNA Helicases | — | 169 |
| 5 | Thioctic Acid | — | 298 |
| 6 | Hesperidin | — | 300 |
| 7 | Demeclocycline | — | 5 |
| 8 | Maprotiline | — | 299 |
| 9 | Nortriptyline | — | 295 |
| 10 | Thioctic Acid | — | 300 |
| 11 | Gabapentin | — | 295 |
| 12 | Ethionine 2-Amino-4-(ethylthio)butyric acid. | — | 300 |
About the Presynaptic depolarization and calcium channel opening Pathway
The Presynaptic depolarization and calcium channel opening pathway is catalogued in Reactome (ID: R-HSA-112308) and involves 3 genes. In the BiohacksAI corpus, 12 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CACNA1B, CACNA2D1, CACNA2D2.