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Maprotiline

A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.

299+ PubMed studies analyzed · 42 RCTs · Evidence Score: 47.2

Research Domains

Maprotiline has been studied across 17 research domains including 🌤️ Mood & Depression, 😴 Sleep, 🧠 Focus & Attention, 🧘 Stress & Anxiety, ❤️ Cardiovascular. The primary research focus is 🌤️ Mood & Depression with 48% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Maprotiline, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

Nortriptyline
41 shared targets
Amoxapine
43 shared targets
Promethazine
37 shared targets
Domperidone
33 shared targets
Cyproheptadine
37 shared targets
oxatomide
32 shared targets
Cinnarizine
27 shared targets
Amitriptyline
34 shared targets
Quetiapine
27 shared targets
Flunarizine
30 shared targets
Loading evidence profile...

This evidence profile for Maprotiline is generated deterministically from 299 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.