Formation of RNA Pol II elongation complex
REACTOME PATHWAYThe Formation of RNA Pol II elongation complex pathway (Reactome ID: R-HSA-112382) involves 5 genes and is affected by 16 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Formation of RNA Pol II elongation complex
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Perphenazine | — | 297 |
| 2 | Methylene Blue | — | 200 |
| 3 | Chlorhexidine | — | 299 |
| 4 | Nisoldipine | — | 297 |
| 5 | Thioridazine | — | 35 |
| 6 | Biotin | — | 297 |
| 7 | chlorprothixene hydrochloride | — | 1 |
| 8 | Ethidium | — | 300 |
| 9 | Nitrofurantoin | — | 297 |
| 10 | Nortriptyline | — | 28 |
| 11 | hydroxyfasudil [Supplementary Concept] | — | 11 |
| 12 | pictilisib | — | 25 |
| 13 | Sorafenib | — | 300 |
| 14 | alsterpaullone | — | 12 |
| 15 | kenpaullone | — | 8 |
| 16 | Tripterygium | — | 300 |
About the Formation of RNA Pol II elongation complex Pathway
The Formation of RNA Pol II elongation complex pathway is catalogued in Reactome (ID: R-HSA-112382) and involves 5 genes. In the BiohacksAI corpus, 16 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNT2, CDK7, CDK9, ERCC3, MLLT3.