Tandem pore domain potassium channels
REACTOME PATHWAYThe Tandem pore domain potassium channels pathway (Reactome ID: R-HSA-1296346) involves 6 genes and is affected by 18 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Tandem pore domain potassium channels
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Arachidonic Acid | — | 245 |
| 2 | Carvedilol | — | 296 |
| 3 | Riluzole | — | 298 |
| 4 | Quinidine | — | 298 |
| 5 | auraptene | — | 148 |
| 6 | Clotrimazole | — | 296 |
| 7 | 17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as | — | 287 |
| 8 | Bisphenol A-Glycidyl Methacrylate | — | 197 |
| 9 | Fluoxymesterone | — | 278 |
| 10 | Miconazole | — | 298 |
| 11 | Oxyphenbutazone | — | 300 |
| 12 | Testosterone Propionate | — | 300 |
| 13 | Amlodipine | — | 1,000 |
| 14 | Flunarizine Flunarizine is | — | 299 |
| 15 | Fluspirilene | — | 74 |
| 16 | Dehydroepiandrosterone Sulfate | — | 300 |
| 17 | Linoleic Acid | — | 300 |
| 18 | Lysophosphatidylcholines Derivatives of PHOSPHATIDYLCHOLINES obtained by their partial hydrolysis which removes | — | 300 |
About the Tandem pore domain potassium channels Pathway
The Tandem pore domain potassium channels pathway is catalogued in Reactome (ID: R-HSA-1296346) and involves 6 genes. In the BiohacksAI corpus, 18 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include KCNK10, KCNK16, KCNK18, KCNK2, KCNK3.