Late Phase of HIV Life Cycle
REACTOME PATHWAYThe Late Phase of HIV Life Cycle pathway (Reactome ID: R-HSA-162599) involves 8 genes and is affected by 12 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Late Phase of HIV Life Cycle
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | hydroxyfasudil [Supplementary Concept] | — | 11 |
| 2 | pictilisib | — | 25 |
| 3 | Sorafenib | — | 300 |
| 4 | plumbagin [Supplementary Concept] | — | 300 |
| 5 | oridonin | — | 300 |
| 6 | Diminazene | — | 300 |
| 7 | silver sulfadiazine | — | 299 |
| 8 | alsterpaullone | — | 12 |
| 9 | kenpaullone | — | 8 |
| 10 | Levamisole | — | 299 |
| 11 | Reserpine | — | 297 |
| 12 | Tripterygium | — | 300 |
About the Late Phase of HIV Life Cycle Pathway
The Late Phase of HIV Life Cycle pathway is catalogued in Reactome (ID: R-HSA-162599) and involves 8 genes. In the BiohacksAI corpus, 12 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNT2, CDK7, CDK9, ERCC3, FURIN.