AMPK inhibits chREBP transcriptional activation activity
REACTOME PATHWAYThe AMPK inhibits chREBP transcriptional activation activity pathway (Reactome ID: R-HSA-163680) involves 3 genes and is affected by 13 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting AMPK inhibits chREBP transcriptional activation activity
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Adenosine Monophosphate Adenine nucleotide containing | — | 300 |
| 2 | Proguanil | — | 299 |
| 3 | Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone | — | 76 |
| 4 | Niclosamide | — | 299 |
| 5 | Berberine | — | 300 |
| 6 | Ursolic Acid | — | 300 |
| 7 | Antimycin | — | 300 |
| 8 | Oleanolic Acid | — | 300 |
| 9 | Rotenone | — | 300 |
| 10 | Metformin | — | 1,000 |
| 11 | Quercetin | — | 300 |
| 12 | Kaempferols | — | 300 |
| 13 | Rutin | — | 300 |
About the AMPK inhibits chREBP transcriptional activation activity Pathway
The AMPK inhibits chREBP transcriptional activation activity pathway is catalogued in Reactome (ID: R-HSA-163680) and involves 3 genes. In the BiohacksAI corpus, 13 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PRKAA2, PRKAB2, PRKAG2.