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Metformin

A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)

1.0k+ PubMed studies analyzed · 353 RCTs · Evidence Score: 73.4

Research Domains

Metformin has been studied across 16 research domains including 🔥 Metabolic, 🧬 Hormones, 🔬 Oncology, ❤️ Cardiovascular, ♀♂ Sexual Health. The primary research focus is 🔥 Metabolic with 88% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Metformin, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

Proguanil
7 shared targets
Berberine
7 shared targets
Antimycin
7 shared targets
Adenosine
7 shared targets
Carbonyl
7 shared targets
Oleanolic
9 shared targets
Oseltamivir
3 shared targets
Lamivudine
3 shared targets
Ursolic
8 shared targets
Valsartan
3 shared targets
Loading evidence profile...

This evidence profile for Metformin is generated deterministically from 1,005 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.