Nef and signal transduction
REACTOME PATHWAYThe Nef and signal transduction pathway (Reactome ID: R-HSA-164944) involves 3 genes and is affected by 14 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Nef and signal transduction
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | Dasatinib | — | 299 |
| 3 | tyrphostin ag 1478 | — | 4 |
| 4 | Crizotinib | — | 298 |
| 5 | kenpaullone | — | 8 |
| 6 | Acetic Acid Product of | — | 300 |
| 7 | Afatinib | — | 297 |
| 8 | Axitinib | — | 298 |
| 9 | piceatannol | — | 300 |
| 10 | sp600125 | — | 117 |
| 11 | Swainsonine | — | 300 |
| 12 | Rosmarinic Acid | — | 300 |
| 13 | Genistein | — | 300 |
| 14 | egcg | — | 300 |
About the Nef and signal transduction Pathway
The Nef and signal transduction pathway is catalogued in Reactome (ID: R-HSA-164944) and involves 3 genes. In the BiohacksAI corpus, 14 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FYN, HCK, LCK.