Tat-mediated elongation of the HIV-1 transcript
REACTOME PATHWAYThe Tat-mediated elongation of the HIV-1 transcript pathway (Reactome ID: R-HSA-167246) involves 3 genes and is affected by 5 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Tat-mediated elongation of the HIV-1 transcript
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | hydroxyfasudil [Supplementary Concept] | — | 11 |
| 2 | pictilisib | — | 25 |
| 3 | Sorafenib | — | 300 |
| 4 | alsterpaullone | — | 12 |
| 5 | Tripterygium | — | 300 |
About the Tat-mediated elongation of the HIV-1 transcript Pathway
The Tat-mediated elongation of the HIV-1 transcript pathway is catalogued in Reactome (ID: R-HSA-167246) and involves 3 genes. In the BiohacksAI corpus, 5 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK7, CDK9, ERCC3.