What compounds affect the p38MAPK events pathway?

21 compounds in the BiohacksAI corpus have documented interactions with genes in the p38MAPK events pathway (Reactome ID: R-HSA-171007). These compounds target 6 genes within this pathway.

What genes are in the p38MAPK events pathway?

The p38MAPK events pathway involves 6 genes. Key genes include: MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, SRC.

p38MAPK events

REACTOME PATHWAY

Reactome: R-HSA-1710076 genes21 compounds

The p38MAPK events pathway (Reactome ID: R-HSA-171007) involves 6 genes and is affected by 21 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

MAPK11 MAPK12 MAPK13 MAPK14 MAPKAPK2 SRC

Compounds Affecting p38MAPK events

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Afatinib	—	297
3	Anisomycin	—	247
4	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
5	withaferin	—	300
6	Dasatinib	—	299
7	Quercetin	—	300
8	tyrphostin ag 1478	—	4
9	egcg	—	300
10	fisetin	—	78
11	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
12	Celecoxib	—	295
13	Resveratrol	—	298
14	Adenosine Monophosphate Adenine nucleotide containing	—	300
15	alsterpaullone	—	12
16	Crizotinib	—	298
17	kenpaullone	—	8
18	monorden	—	8
19	Niclosamide	—	299
20	sp600125	—	117
21	Adenosine Triphosphate	—	300

About the p38MAPK events Pathway

The p38MAPK events pathway is catalogued in Reactome (ID: R-HSA-171007) and involves 6 genes. In the BiohacksAI corpus, 21 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2.