Gap junction trafficking
REACTOME PATHWAYThe Gap junction trafficking pathway (Reactome ID: R-HSA-190828) involves 18 genes and is affected by 10 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Gap junction trafficking
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Colchicine | — | 300 |
| 2 | Nocodazole Nocodazole is | — | 215 |
| 3 | Vincristine | — | 299 |
| 4 | Noscapine | — | 300 |
| 5 | Podophyllotoxin | — | 14 |
| 6 | Demecolcine | — | 246 |
| 7 | Maytansine | — | 300 |
| 8 | vinblastine sulfate | — | 81 |
| 9 | Vorinostat | — | 299 |
| 10 | Kanamycin Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, | — | 300 |
About the Gap junction trafficking Pathway
The Gap junction trafficking pathway is catalogued in Reactome (ID: R-HSA-190828) and involves 18 genes. In the BiohacksAI corpus, 10 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GJB2, TUBA1A, TUBA1B, TUBA1C, TUBA3C.