Cholesterol biosynthesis
REACTOME PATHWAYThe Cholesterol biosynthesis pathway (Reactome ID: R-HSA-191273) involves 5 genes and is affected by 12 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Cholesterol biosynthesis
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Atorvastatin | — | 1,000 |
| 2 | Lovastatin | — | 300 |
| 3 | Simvastatin | — | 1,000 |
| 4 | Pravastatin | — | 297 |
| 5 | Artemether | — | 299 |
| 6 | Rosuvastatin Calcium | — | 216 |
| 7 | Clotrimazole | — | 296 |
| 8 | Econazole | — | 299 |
| 9 | Miconazole | — | 298 |
| 10 | Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is | — | 270 |
| 11 | Zoledronic Acid | — | 299 |
| 12 | Calcifediol | — | 300 |
About the Cholesterol biosynthesis Pathway
The Cholesterol biosynthesis pathway is catalogued in Reactome (ID: R-HSA-191273) and involves 5 genes. In the BiohacksAI corpus, 12 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CYP51A1, FDPS, HMGCR, SREBF1, SREBF2.