What compounds affect the snRNP Assembly pathway?

23 compounds in the BiohacksAI corpus have documented interactions with genes in the snRNP Assembly pathway (Reactome ID: R-HSA-191859). These compounds target 5 genes within this pathway.

What genes are in the snRNP Assembly pathway?

The snRNP Assembly pathway involves 5 genes. Key genes include: PRMT5, SMN1, SMN2, SNUPN, WDR77.

snRNP Assembly

REACTOME PATHWAY

Reactome: R-HSA-1918595 genes23 compounds

The snRNP Assembly pathway (Reactome ID: R-HSA-191859) involves 5 genes and is affected by 23 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

PRMT5 SMN1 SMN2 SNUPN WDR77

Compounds Affecting snRNP Assembly

#	Compound	Targets Hit	Studies
1	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
2	Niclosamide	—	299
3	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
4	s adenosylhomocysteine	—	300
5	same	—	299
6	s adenosylmethionine	—	300
7	Leflunomide	—	297
8	Pueraria	—	300
9	Genistein	—	300
10	Resveratrol	—	298
11	pd98059	—	7
12	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
13	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
14	Bromodeoxyuridine	—	300
15	kenpaullone	—	8
16	chrysin	—	300
17	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
18	Azauridine	—	300
19	Lovastatin	—	300
20	piceatannol	—	300
21	tyrphostin ag 1295	—	1
22	Chlorhexidine	—	299
23	Reserpine	—	297

About the snRNP Assembly Pathway

The snRNP Assembly pathway is catalogued in Reactome (ID: R-HSA-191859) and involves 5 genes. In the BiohacksAI corpus, 23 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PRMT5, SMN1, SMN2, SNUPN, WDR77.