Metabolism of folate and pterines
REACTOME PATHWAYThe Metabolism of folate and pterines pathway (Reactome ID: R-HSA-196757) involves 5 genes and is affected by 9 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Metabolism of folate and pterines
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Methotrexate | — | 289 |
| 2 | Pemetrexed | — | 299 |
| 3 | Leucovorin | — | 297 |
| 4 | egcg | — | 300 |
| 5 | Folic Acid | — | 296 |
| 6 | Sulfadiazine | — | 298 |
| 7 | Duloxetine Hydrochloride | — | 993 |
| 8 | Oxaprozin | — | 181 |
| 9 | Papaverine | — | 299 |
About the Metabolism of folate and pterines Pathway
The Metabolism of folate and pterines pathway is catalogued in Reactome (ID: R-HSA-196757) and involves 5 genes. In the BiohacksAI corpus, 9 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include DHFR, FPGS, SHMT2, SLC19A1, SLC46A1.