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Leucovorin

The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.

297+ PubMed studies analyzed · 52 RCTs · Evidence Score: 53.1

Research Domains

Leucovorin has been studied across 11 research domains including 🔬 Oncology, ⏳ Longevity & Aging, 🦴 Bone & Joint, 🫁 Liver & Detox, 🦠 Gut & Microbiome. The primary research focus is 🔬 Oncology with 67% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Leucovorin, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

pralatrexate
3 shared targets
raltitrexed
3 shared targets
methotrexate
3 shared targets
Pemetrexed
3 shared targets
Methotrexate
4 shared targets
dendrobium
2 shared targets
sanguisorba
2 shared targets
alisma
2 shared targets
allium
2 shared targets
Raphanus
2 shared targets
Loading evidence profile...

This evidence profile for Leucovorin is generated deterministically from 297 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.