What compounds affect the WNT mediated activation of DVL pathway?

21 compounds in the BiohacksAI corpus have documented interactions with genes in the WNT mediated activation of DVL pathway (Reactome ID: R-HSA-201688). These compounds target 4 genes within this pathway.

What genes are in the WNT mediated activation of DVL pathway?

The WNT mediated activation of DVL pathway involves 4 genes. Key genes include: CSNK1E, CSNK2A1, CSNK2A2, CSNK2B.

WNT mediated activation of DVL

REACTOME PATHWAY

Reactome: R-HSA-2016884 genes21 compounds

The WNT mediated activation of DVL pathway (Reactome ID: R-HSA-201688) involves 4 genes and is affected by 21 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CSNK1E CSNK2A1 CSNK2A2 CSNK2B

Compounds Affecting WNT mediated activation of DVL

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
3	Quercetin	—	300
4	fisetin	—	78
5	Kaempferols	—	300
6	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
7	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
8	chrysin	—	300
9	Vanillic Acid	—	300
10	ly294002	—	11
11	sp600125	—	117
12	pictilisib	—	25
13	Dichlororibofuranosylbenzimidazole	—	26
14	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
15	alsterpaullone	—	12
16	kenpaullone	—	8
17	Axitinib	—	298
18	egcg	—	300
19	Afatinib	—	297
20	Dasatinib	—	299
21	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300

About the WNT mediated activation of DVL Pathway

The WNT mediated activation of DVL pathway is catalogued in Reactome (ID: R-HSA-201688) and involves 4 genes. In the BiohacksAI corpus, 21 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CSNK1E, CSNK2A1, CSNK2A2, CSNK2B.