Metabolism of Angiotensinogen to Angiotensins
REACTOME PATHWAYThe Metabolism of Angiotensinogen to Angiotensins pathway (Reactome ID: R-HSA-2022377) involves 5 genes and is affected by 10 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Metabolism of Angiotensinogen to Angiotensins
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Thiorphan | — | 300 |
| 2 | Bortezomib | — | 300 |
| 3 | Lisinopril | — | 904 |
| 4 | Enalapril | — | 297 |
| 5 | Fosinopril | — | 296 |
| 6 | Losartan | — | 1,000 |
| 7 | Bradykinin | — | 299 |
| 8 | Vorinostat | — | 299 |
| 9 | Ursolic Acid | — | 300 |
| 10 | Oleanolic Acid | — | 300 |
About the Metabolism of Angiotensinogen to Angiotensins Pathway
The Metabolism of Angiotensinogen to Angiotensins pathway is catalogued in Reactome (ID: R-HSA-2022377) and involves 5 genes. In the BiohacksAI corpus, 10 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ACE, CES1, CMA1, CTSG, MME.