MHC class II antigen presentation
REACTOME PATHWAYThe MHC class II antigen presentation pathway (Reactome ID: R-HSA-2132295) involves 22 genes and is affected by 18 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting MHC class II antigen presentation
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Colchicine | — | 300 |
| 2 | Nocodazole Nocodazole is | — | 215 |
| 3 | Vincristine | — | 299 |
| 4 | Noscapine | — | 300 |
| 5 | Podophyllotoxin | — | 14 |
| 6 | Demecolcine | — | 246 |
| 7 | Maytansine | — | 300 |
| 8 | vinblastine sulfate | — | 81 |
| 9 | Vorinostat | — | 299 |
| 10 | Pueraria | — | 300 |
| 11 | Kaempferols | — | 300 |
| 12 | Catechin | — | 300 |
| 13 | Equilin | — | 216 |
| 14 | Guanosine Diphosphate | — | 300 |
| 15 | Guanosine Triphosphate Guanosine 5'-(tetrahydrogen triphosphate). | — | 300 |
| 16 | Bortezomib | — | 300 |
| 17 | Crizotinib | — | 298 |
| 18 | Triamcinolone | — | 300 |
About the MHC class II antigen presentation Pathway
The MHC class II antigen presentation pathway is catalogued in Reactome (ID: R-HSA-2132295) and involves 22 genes. In the BiohacksAI corpus, 18 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CD74, CTSA, CTSL, RAB7A, RACGAP1.