Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate

Q: What compounds affect the Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate pathway?

46 compounds in the BiohacksAI corpus have documented interactions with genes in the Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate pathway (Reactome ID: R-HSA-2978092). These compounds target 1 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-29780921 genes46 compounds

The Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate pathway (Reactome ID: R-HSA-2978092) involves 1 genes and is affected by 46 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

IDH1

Compounds Affecting Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate

#	Compound	Targets Hit	Studies
1	licochalcone	—	267
2	Mometasone Furoate	—	292
3	Dinitrochlorobenzene	—	300
4	Lovastatin	—	300
5	Methylene Blue	—	200
6	Sertraline	—	1,000
7	Simvastatin	—	1,000
8	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
9	2-Chloroadenosine 2-Chloroadenosine.	—	300
10	6-Aminonicotinamide	—	300
11	Methotrexate	—	289
12	Anisomycin	—	247
13	Astemizole Antihistamine drug now withdrawn from	—	280
14	Azacitidine	—	298
15	Azacitidine	—	300
16	Azathioprine	—	300
17	Calcimycin	—	216
18	Carbazilquinone	—	48
19	Chlorhexidine	—	299
20	Ciclopirox	—	88
21	clofilium tosylate	—	4
22	colchine	—	2
23	cycloheximide	—	300
24	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
25	Digitoxin	—	300
26	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
27	Digoxin	—	299
28	Ethinyl Estradiol	—	300
29	Fluspirilene	—	74
30	Hexachlorophene	—	300
31	Imatinib Mesylate	—	300
32	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
33	Miconazole	—	298
34	Niclosamide	—	299
35	Nisoldipine	—	297
36	Nortriptyline	—	28
37	propionylpromazine hydrochloride	—	2
38	Quinestrol	—	194
39	Salmeterol Xinafoate	—	227
40	streptonigrin	—	299
41	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
42	Thioridazine	—	35
43	triflupromazine hydrochloride	—	12
44	Tubercidin	—	300
45	tyrphostin 9	—	2
46	vinblastine sulfate	—	81

About the Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate Pathway

The Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate pathway is catalogued in Reactome (ID: R-HSA-2978092) and involves 1 genes. In the BiohacksAI corpus, 46 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include IDH1.