SUMO is conjugated to E1 (UBA2:SAE1)
REACTOME PATHWAYThe SUMO is conjugated to E1 (UBA2:SAE1) pathway (Reactome ID: R-HSA-3065676) involves 3 genes and is affected by 12 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting SUMO is conjugated to E1 (UBA2:SAE1)
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Hexachlorophene | — | 300 |
| 2 | DEAD-box RNA Helicases | — | 169 |
| 3 | Thioctic Acid | — | 298 |
| 4 | Thioctic Acid | — | 300 |
| 5 | Rosmarinic Acid | — | 300 |
| 6 | Demeclocycline | — | 5 |
| 7 | Edaravone | — | 298 |
| 8 | Methyldopa | — | 297 |
| 9 | rafoxanide | — | 172 |
| 10 | Cefdinir | — | 298 |
| 11 | Cefixime | — | 300 |
| 12 | Oxytetracycline | — | 300 |
About the SUMO is conjugated to E1 (UBA2:SAE1) Pathway
The SUMO is conjugated to E1 (UBA2:SAE1) pathway is catalogued in Reactome (ID: R-HSA-3065676) and involves 3 genes. In the BiohacksAI corpus, 12 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include SAE1, SUMO1, UBA2.