HDMs demethylate histones
REACTOME PATHWAYThe HDMs demethylate histones pathway (Reactome ID: R-HSA-3214842) involves 6 genes and is affected by 9 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting HDMs demethylate histones
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | 19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept] | — | 300 |
| 2 | triolimus [Supplementary Concept] | — | 33 |
| 3 | Deferasirox | — | 298 |
| 4 | Phenelzine | — | 297 |
| 5 | Berberine | — | 300 |
| 6 | Quercetin | — | 300 |
| 7 | Rutin | — | 300 |
| 8 | Deferoxamine Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as | — | 296 |
| 9 | caffeic acid | — | 300 |
About the HDMs demethylate histones Pathway
The HDMs demethylate histones pathway is catalogued in Reactome (ID: R-HSA-3214842) and involves 6 genes. In the BiohacksAI corpus, 9 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include KDM1A, KDM4A, KDM4B, KDM4C, KDM5B.