Processing and activation of SUMO
REACTOME PATHWAYThe Processing and activation of SUMO pathway (Reactome ID: R-HSA-3215018) involves 5 genes and is affected by 15 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Processing and activation of SUMO
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Hexachlorophene | — | 300 |
| 2 | DEAD-box RNA Helicases | — | 169 |
| 3 | Thioctic Acid | — | 298 |
| 4 | Thioctic Acid | — | 300 |
| 5 | Rosmarinic Acid | — | 300 |
| 6 | Demeclocycline | — | 5 |
| 7 | Edaravone | — | 298 |
| 8 | Methyldopa | — | 297 |
| 9 | rafoxanide | — | 172 |
| 10 | streptonigrin | — | 299 |
| 11 | Ethylmaleimide | — | 300 |
| 12 | Cefdinir | — | 298 |
| 13 | Cefixime | — | 300 |
| 14 | Oxytetracycline | — | 300 |
| 15 | Ursolic Acid | — | 300 |
About the Processing and activation of SUMO Pathway
The Processing and activation of SUMO pathway is catalogued in Reactome (ID: R-HSA-3215018) and involves 5 genes. In the BiohacksAI corpus, 15 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include SAE1, SENP1, SENP2, SUMO1, UBA2.