Class B/2 (Secretin family receptors)
REACTOME PATHWAYThe Class B/2 (Secretin family receptors) pathway (Reactome ID: R-HSA-373080) involves 12 genes and is affected by 29 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Class B/2 (Secretin family receptors)
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Niclosamide | — | 299 |
| 2 | Secretin | — | 299 |
| 3 | Glucagon-Like Peptide 2 | — | 300 |
| 4 | Liraglutide | — | 999 |
| 5 | Levalbuterol | — | 1,000 |
| 6 | Semaglutide | — | 999 |
| 7 | 2-Methoxyestradiol | — | 300 |
| 8 | Levalbuterol | — | 297 |
| 9 | Azauridine | — | 300 |
| 10 | Clotrimazole | — | 296 |
| 11 | cycloheximide | — | 300 |
| 12 | Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide. | — | 300 |
| 13 | Dihydroergotamine | — | 9 |
| 14 | Ethidium | — | 300 |
| 15 | Nortriptyline | — | 28 |
| 16 | Perphenazine | — | 297 |
| 17 | propionylpromazine hydrochloride | — | 2 |
| 18 | Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide. | — | 300 |
| 19 | Calcimycin | — | 216 |
| 20 | Sarcosine | — | 300 |
| 21 | Sulfachlorpyridazine | — | 52 |
| 22 | tyrphostin 9 | — | 2 |
| 23 | Tetraethylammonium | — | 119 |
| 24 | Triacetin | — | 300 |
| 25 | urolithin b | — | 49 |
| 26 | antalarmin | — | 31 |
| 27 | Calcitonin | — | 298 |
| 28 | Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on | — | 299 |
| 29 | tesamorelin [Supplementary Concept] | — | 81 |
About the Class B/2 (Secretin family receptors) Pathway
The Class B/2 (Secretin family receptors) pathway is catalogued in Reactome (ID: R-HSA-373080) and involves 12 genes. In the BiohacksAI corpus, 29 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CALCR, CRHBP, CRHR1, FZD1, GHRHR.