What compounds affect the IRE1alpha activates chaperones pathway?

21 compounds in the BiohacksAI corpus have documented interactions with genes in the IRE1alpha activates chaperones pathway (Reactome ID: R-HSA-381070). These compounds target 5 genes within this pathway.

What genes are in the IRE1alpha activates chaperones pathway?

The IRE1alpha activates chaperones pathway involves 5 genes. Key genes include: ERN1, GSK3A, HSPA5, LMNA, XBP1.

IRE1alpha activates chaperones

REACTOME PATHWAY

Reactome: R-HSA-3810705 genes21 compounds

The IRE1alpha activates chaperones pathway (Reactome ID: R-HSA-381070) involves 5 genes and is affected by 21 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ERN1 GSK3A HSPA5 LMNA XBP1

Compounds Affecting IRE1alpha activates chaperones

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	alsterpaullone	—	12
3	indirubin	—	300
4	kenpaullone	—	8
5	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	chrysin	—	300
8	fisetin	—	78
9	Kaempferols	—	300
10	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
11	Quercetin	—	300
12	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
13	Chlorhexidine	—	299
14	piceatannol	—	300
15	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
16	Hexachlorophene	—	300
17	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
18	Ergosterol	—	300
19	Calcimycin	—	216
20	Fluspirilene	—	74
21	Histamine	—	300

About the IRE1alpha activates chaperones Pathway

The IRE1alpha activates chaperones pathway is catalogued in Reactome (ID: R-HSA-381070) and involves 5 genes. In the BiohacksAI corpus, 21 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ERN1, GSK3A, HSPA5, LMNA, XBP1.