What genes are in the Beta-catenin independent WNT signaling pathway?

The Beta-catenin independent WNT signaling pathway involves 40 genes. Key genes include: ADRM1, AGO2, FZD1, GNAO1, MAP3K7, NLK, PDE6A, PLCB3, PSMA1, PSMA2.

Beta-catenin independent WNT signaling

Q: What compounds affect the Beta-catenin independent WNT signaling pathway?

26 compounds in the BiohacksAI corpus have documented interactions with genes in the Beta-catenin independent WNT signaling pathway (Reactome ID: R-HSA-3858494). These compounds target 40 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-385849440 genes26 compounds

The Beta-catenin independent WNT signaling pathway (Reactome ID: R-HSA-3858494) involves 40 genes and is affected by 26 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AGO2 FZD1 GNAO1 MAP3K7 NLK PDE6A PLCB3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11+10 more

Compounds Affecting Beta-catenin independent WNT signaling

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	egcg	—	300
4	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
5	Sorafenib	—	300
6	Disulfiram	—	297
7	4-Hydroxybenzoate-3-Monooxygenase	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	chrysin	—	300
10	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
11	Quercetin	—	300
12	Genistein	—	300
13	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
14	Adenosine	—	298
15	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
16	Adenosine Triphosphate	—	300
17	Crizotinib	—	298
18	Pioglitazone	—	297
19	Harmaline	—	300
20	Cefixime	—	300
21	Emtricitabine	—	292
22	Dasatinib	—	299
23	Antazoline	—	229
24	Niclosamide	—	299
25	pnu74654	—	6
26	Sulfisomidine	—	73

About the Beta-catenin independent WNT signaling Pathway

The Beta-catenin independent WNT signaling pathway is catalogued in Reactome (ID: R-HSA-3858494) and involves 40 genes. In the BiohacksAI corpus, 26 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AGO2, FZD1, GNAO1, MAP3K7.