Prefoldin mediated transfer of substrate to CCT/TriC
REACTOME PATHWAYThe Prefoldin mediated transfer of substrate to CCT/TriC pathway (Reactome ID: R-HSA-389957) involves 12 genes and is affected by 10 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Prefoldin mediated transfer of substrate to CCT/TriC
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Colchicine | — | 300 |
| 2 | Nocodazole Nocodazole is | — | 215 |
| 3 | Podophyllotoxin | — | 14 |
| 4 | Vincristine | — | 299 |
| 5 | Demecolcine | — | 246 |
| 6 | Maytansine | — | 300 |
| 7 | Noscapine | — | 300 |
| 8 | vinblastine sulfate | — | 81 |
| 9 | Vorinostat | — | 299 |
| 10 | Methylene Blue | — | 200 |
About the Prefoldin mediated transfer of substrate to CCT/TriC Pathway
The Prefoldin mediated transfer of substrate to CCT/TriC pathway is catalogued in Reactome (ID: R-HSA-389957) and involves 12 genes. In the BiohacksAI corpus, 10 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCT2, TUBA1A, TUBA1C, TUBA3C, TUBA4A.