What compounds affect the Signal amplification pathway?

68 compounds in the BiohacksAI corpus have documented interactions with genes in the Signal amplification pathway (Reactome ID: R-HSA-392518). These compounds target 7 genes within this pathway.

What genes are in the Signal amplification pathway?

The Signal amplification pathway involves 7 genes. Key genes include: GNA15, GNAI1, MAPK14, P2RY1, P2RY12, SRC, TBXA2R.

Signal amplification

REACTOME PATHWAY

Reactome: R-HSA-3925187 genes68 compounds

The Signal amplification pathway (Reactome ID: R-HSA-392518) involves 7 genes and is affected by 68 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GNA15 GNAI1 MAPK14 P2RY1 P2RY12 SRC TBXA2R

Compounds Affecting Signal amplification

#	Compound	Targets Hit	Studies
1	tyrphostin ag 1478	—	4
2	Aripiprazole	—	298
3	Nicergoline	—	300
4	Ticagrelor	—	299
5	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
6	Sorafenib	—	300
7	Dasatinib	—	299
8	Afatinib	—	297
9	Quercetin	—	300
10	Adenosine Monophosphate Adenine nucleotide containing	—	300
11	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
12	Adenosine Triphosphate	—	300
13	Suramin	—	300
14	Dinoprost	—	252
15	Dinoprostone	—	296
16	Amlodipine	—	1,000
17	cbd	—	298
18	Losartan	—	1,000
19	Simvastatin	—	1,000
20	Axitinib	—	298
21	candesartan cilexetil [Supplementary Concept]	—	300
22	cannabidiol	—	296
23	Cloprostenol	—	300
24	Enoxacin	—	299
25	Epirubicin	—	300
26	Ezetimibe	—	296
27	Flutamide	—	298
28	Irbesartan	—	298
29	Micafungin	—	300
30	Norethindrone Acetate Acetate ester of norethindrone that is used as	—	300
31	Pioglitazone	—	297
32	Rifamycins	—	300
33	Rifamycins	—	300
34	Ritonavir	—	298
35	Thiethylperazine	—	165
36	Aurintricarboxylic Acid	—	184
37	Daunorubicin	—	298
38	Ethidium	—	300
39	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
40	Rosmarinic Acid	—	300
41	Allantoin	—	300
42	Diiodotyrosine	—	300
43	Dimethylphenylpiperazinium Iodide	—	33
44	Dipyrone	—	298
45	Idarubicin	—	299
46	iodoform	—	272
47	Pseudoephedrine	—	298
48	tiopronin	—	299
49	egcg	—	300
50	fisetin	—	78

About the Signal amplification Pathway

The Signal amplification pathway is catalogued in Reactome (ID: R-HSA-392518) and involves 7 genes. In the BiohacksAI corpus, 68 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GNA15, GNAI1, MAPK14, P2RY1, P2RY12.