What compounds affect the PCP/CE pathway pathway?

15 compounds in the BiohacksAI corpus have documented interactions with genes in the PCP/CE pathway pathway (Reactome ID: R-HSA-4086400). These compounds target 33 genes within this pathway.

What genes are in the PCP/CE pathway pathway?

The PCP/CE pathway pathway involves 33 genes. Key genes include: ADRM1, FZD1, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1.

PCP/CE pathway

REACTOME PATHWAY

Reactome: R-HSA-408640033 genes15 compounds

The PCP/CE pathway pathway (Reactome ID: R-HSA-4086400) involves 33 genes and is affected by 15 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 FZD1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6+3 more

Compounds Affecting PCP/CE pathway

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
4	Disulfiram	—	297
5	4-Hydroxybenzoate-3-Monooxygenase	—	300
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	chrysin	—	300
8	egcg	—	300
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	Quercetin	—	300
11	Genistein	—	300
12	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
13	Pioglitazone	—	297
14	Harmaline	—	300
15	Niclosamide	—	299

About the PCP/CE pathway Pathway

The PCP/CE pathway pathway is catalogued in Reactome (ID: R-HSA-4086400) and involves 33 genes. In the BiohacksAI corpus, 15 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, FZD1, PSMA1, PSMA2, PSMA3.