What genes are in the ADP signalling through P2Y purinoceptor 1 pathway?

The ADP signalling through P2Y purinoceptor 1 pathway involves 4 genes. Key genes include: GNA15, MAPK14, P2RY1, SRC.

ADP signalling through P2Y purinoceptor 1

Q: What compounds affect the ADP signalling through P2Y purinoceptor 1 pathway?

30 compounds in the BiohacksAI corpus have documented interactions with genes in the ADP signalling through P2Y purinoceptor 1 pathway (Reactome ID: R-HSA-418592). These compounds target 4 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-4185924 genes30 compounds

The ADP signalling through P2Y purinoceptor 1 pathway (Reactome ID: R-HSA-418592) involves 4 genes and is affected by 30 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GNA15 MAPK14 P2RY1 SRC

Compounds Affecting ADP signalling through P2Y purinoceptor 1

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Dasatinib	—	299
3	Afatinib	—	297
4	Quercetin	—	300
5	tyrphostin ag 1478	—	4
6	Adenosine Monophosphate Adenine nucleotide containing	—	300
7	egcg	—	300
8	fisetin	—	78
9	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
10	Anisomycin	—	247
11	Celecoxib	—	295
12	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
13	withaferin	—	300
14	Resveratrol	—	298
15	alsterpaullone	—	12
16	Crizotinib	—	298
17	kenpaullone	—	8
18	monorden	—	8
19	Niclosamide	—	299
20	Aripiprazole	—	298
21	Bisphenol A-Glycidyl Methacrylate	—	197
22	Calcimycin	—	216
23	Equilin	—	216
24	Fluspirilene	—	74
25	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
26	Sphingosine	—	300
27	Astemizole Antihistamine drug now withdrawn from	—	280
28	Adenosine Triphosphate	—	300
29	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
30	Suramin	—	300

About the ADP signalling through P2Y purinoceptor 1 Pathway

The ADP signalling through P2Y purinoceptor 1 pathway is catalogued in Reactome (ID: R-HSA-418592) and involves 4 genes. In the BiohacksAI corpus, 30 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GNA15, MAPK14, P2RY1, SRC.