Glucagon-type ligand receptors
REACTOME PATHWAYThe Glucagon-type ligand receptors pathway (Reactome ID: R-HSA-420092) involves 7 genes and is affected by 22 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Glucagon-type ligand receptors
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Secretin | — | 299 |
| 2 | Glucagon-Like Peptide 2 | — | 300 |
| 3 | Liraglutide | — | 999 |
| 4 | Levalbuterol | — | 1,000 |
| 5 | Semaglutide | — | 999 |
| 6 | 2-Methoxyestradiol | — | 300 |
| 7 | Levalbuterol | — | 297 |
| 8 | Azauridine | — | 300 |
| 9 | Clotrimazole | — | 296 |
| 10 | cycloheximide | — | 300 |
| 11 | Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide. | — | 300 |
| 12 | Dihydroergotamine | — | 9 |
| 13 | Ethidium | — | 300 |
| 14 | Nortriptyline | — | 28 |
| 15 | Perphenazine | — | 297 |
| 16 | propionylpromazine hydrochloride | — | 2 |
| 17 | Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide. | — | 300 |
| 18 | Niclosamide | — | 299 |
| 19 | Tetraethylammonium | — | 119 |
| 20 | Triacetin | — | 300 |
| 21 | urolithin b | — | 49 |
| 22 | tesamorelin [Supplementary Concept] | — | 81 |
About the Glucagon-type ligand receptors Pathway
The Glucagon-type ligand receptors pathway is catalogued in Reactome (ID: R-HSA-420092) and involves 7 genes. In the BiohacksAI corpus, 22 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GHRHR, GLP1R, GLP2R, GNAS, SCTR.