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BiohacksAI

Evidence-Based Biohacking

Patent Pending

Class C/3 (Metabotropic glutamate/pheromone receptors)

REACTOME PATHWAY
Reactome: R-HSA-42049936 genes16 compounds

The Class C/3 (Metabotropic glutamate/pheromone receptors) pathway (Reactome ID: R-HSA-420499) involves 36 genes and is affected by 16 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CASRGABBR1GABBR2GRM1GRM2GRM3GRM4GRM5GRM6GRM7GRM8TAS1R3TAS2R1TAS2R10TAS2R13TAS2R14TAS2R16TAS2R19TAS2R20TAS2R3TAS2R30TAS2R31TAS2R38TAS2R39TAS2R4TAS2R40TAS2R41TAS2R42TAS2R43TAS2R46+6 more

Compounds Affecting Class C/3 (Metabotropic glutamate/pheromone receptors)

#CompoundTargets HitStudies
1Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on—299
2Glutamic Acid—297
3Glutamic Acid—300
4Ibotenic Acid—300
5Strychnine—300
6gamma-Aminobutyric Acid—300
7cinacalcet—298
8Tryptophan—300
9Framycetin—200
10neomycin—298
11Spermine—300
12amn082—29
13Phenylthiourea Phenylthiourea is—300
14Ethylenethiourea—300
15Miconazole—298
16Sucrose—299

About the Class C/3 (Metabotropic glutamate/pheromone receptors) Pathway

The Class C/3 (Metabotropic glutamate/pheromone receptors) pathway is catalogued in Reactome (ID: R-HSA-420499) and involves 36 genes. In the BiohacksAI corpus, 16 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CASR, GABBR1, GABBR2, GRM1, GRM2.